Bayesian network prior: network analysis of biological data using external knowledge

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dc.WoS.categoriesBiochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probabilityen_US
dc.authorid0000-0002-9253-8152en_US
dc.authorid0000-0002-6547-6638en_US
dc.contributor.authorOtu, Hasan H.
dc.contributor.authorDoğan, Haluk
dc.contributor.authorİşçi, Şenol
dc.contributor.authorÖztürk, Cengizhan
dc.date.accessioned2021-02-25T10:55:42Z
dc.date.available2021-02-25T10:55:42Z
dc.date.issued2014-03-15
dc.description.abstractMotivation: Reverse engineering GI networks from experimental data is a challenging task due to the complex nature of the networks and the noise inherent in the data. One way to overcome these hurdles would be incorporating the vast amounts of external biological knowledge when building interaction networks. We propose a framework where GI networks are learned from experimental data using Bayesian networks (BNs) and the incorporation of external knowledge is also done via a BN that we call Bayesian Network Prior (BNP). BNP depicts the relation between various evidence types that contribute to the event 'gene interaction' and is used to calculate the probability of a candidate graph (G) in the structure learning process. Results: Our simulation results on synthetic, simulated and real biological data show that the proposed approach can identify the underlying interaction network with high accuracy even when the prior information is distorted and outperforms existing methods.en_US
dc.fullTextLevelFull Texten_US
dc.identifier.doi10.1093/bioinformatics/btt643en_US
dc.identifier.issn1460-2059
dc.identifier.issn1367-4803
dc.identifier.pmid24215027en_US
dc.identifier.scopus2-s2.0-84897891549en_US
dc.identifier.urihttps://hdl.handle.net/11411/3308
dc.identifier.urihttps://doi.org/10.1093/bioinformatics/btt643
dc.identifier.wosWOS:000333249900017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.issue6en_US
dc.language.isoenen_US
dc.nationalInternationalen_US
dc.numberofauthors4en_US
dc.pages860-867en_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofBioinformaticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEXPRESSION DATAen_US
dc.subjectGENEen_US
dc.subjectINFERENCEen_US
dc.titleBayesian network prior: network analysis of biological data using external knowledgeen_US
dc.typeArticleen_US
dc.volume30en_US

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