Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations

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dc.authoridDalgıç, Ali Deniz/0000-0003-2904-1204;
dc.authorwosidDalgıç, Ali Deniz/AAZ-8985-2020
dc.authorwosidAlshemary, Ammar Z./IQS-4694-2023
dc.contributor.authorMotameni, Ali
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorKeskin, Dilek
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-07-18T20:42:29Z
dc.date.available2024-07-18T20:42:29Z
dc.date.issued2022
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractArtificial bone cements have widespread applications in orthopedic and dental surgeries. Nevertheless, there is a need to develop novel materials for artificial bone cements due to limitations like short-service life, weak interaction and attachment with living hard tissue, and the inability to facilitate bone regeneration of calcified tissues rather than replacing them. In the present research, a novel combination of lanthanum (La3+) ions doped dicalcium phosphate (DCP) (La-DCP) and 1.5-3.5 wt.% of graphene oxide (GO) doped La-DCP bone cement materials were successfully synthesized and reported for the first time. Acid/base interaction between La-beta-tricalcium phosphate (La-beta TCP) and monocalcium phosphate monohydrate (MCPM) in the presence of water was the basis for making the La-DCP cements. The synthesized cements were characterized using the XRD, FTIR, FESEM, UV-Vis and TGA techniques. Produced material had La-DCP as in the monetite phase, and La-DCP particles were formed in agglomerates of irregular shapes. The presence of GO enhanced the growth rate of monetite particles, significantly decreased the setting time of the La-DCP bone cement, enhanced mechanical properties and enhanced the adsorption capacity of La-DCP. In vitro studies showed that synthesized GO/La-DCP bone cements were biocompatible, and the proliferation and differentiation properties of human osteosarcoma (Saos-2) cells were significantly improved with the addition of GO. In summary, the synthesized GO/La-DCP bone cement materials, which exhibit good biocompatibility and mechanical properties, have the potential to be employed in bone defect healing.en_US
dc.identifier.doi10.1007/s41779-022-00800-8
dc.identifier.endpage1647en_US
dc.identifier.issn2510-1560
dc.identifier.issn2510-1579
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85138520417en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1633en_US
dc.identifier.urihttps://doi.org/10.1007/s41779-022-00800-8
dc.identifier.urihttps://hdl.handle.net/11411/7278
dc.identifier.volume58en_US
dc.identifier.wosWOS:000856605000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of The Australian Ceramic Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDicalcium Phosphateen_US
dc.subjectLanthanumen_US
dc.subjectGraphene Oxideen_US
dc.subjectMechanical Propertiesen_US
dc.subjectBiological Propertiesen_US
dc.subjectMechanical-Propertiesen_US
dc.subjectPhase-Transformationen_US
dc.subjectProtein Adsorptionen_US
dc.subjectHydroxyapatiteen_US
dc.subjectLanthanumen_US
dc.subjectBrushiteen_US
dc.subjectMineralizationen_US
dc.subjectCompositeen_US
dc.subjectBiocompatibilityen_US
dc.subjectMonetiteen_US
dc.titleGraphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerationsen_US
dc.typeArticleen_US

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