A tactile sensing capsule endoscope employing force sensing cantilevers for tumor diagnosis in the GI tract

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dc.authorid0000-0002-5381-533X
dc.authorid0000-0002-7882-286X
dc.contributor.authorPeker, Furkan
dc.contributor.authorAkcan, O. Gokalp
dc.contributor.authorAtak, Dila
dc.contributor.authorOzata, Ibrahim H.
dc.contributor.authorUymaz, Derya S.
dc.contributor.authorBalik, Emre
dc.contributor.authorFerhanoglu, Onur
dc.date.accessioned2026-04-04T18:55:36Z
dc.date.available2026-04-04T18:55:36Z
dc.date.issued2026
dc.departmentİstanbul Bilgi Üniversitesi
dc.description.abstractThe correlation between tissue elasticity and histopathological diagnosis has brought attention to the develop ment of biomedical devices for in-vivo measurement of tissue biomechanical properties. Towards this aim, we have developed a tactile sensing capsule endoscope to measure tissue Young's modulus, in situ. Inspired by force microscopy, the capsule comprises four cantilevers that probe the walls of the GI tract using a single miniaturized actuator. The force exerted on the cantilever tip by the tissue is measured using the piezoelectric layer integrated on the cantilevers. The tactile-based modulus sensing capsule was initially tested on ex-vivo animal tissue, fol lowed by healthy and cancerous human specimens. The results clearly delineate the differences in mechanical properties, with a Young's modulus of 11.3 +/- 2.3 kPa for healthy and 26.8 +/- 4.6 kPa for cancerous tissue. Overall, in the realm of tactile-based modulus sensing of tissues, our technology uniquely combines localized, quantitative Young's modulus measurements with the capability to perform multiple measurements throughout the GI tract wall in a single procedure. Moreover, the developed sensor has a compact form factor, in accordance with the capsule dimensions, and simple manufacturing steps using stereolithography. With further improvements, the developed medical device can be utilized as a non-invasive diagnostic tool in the clinic.
dc.description.sponsorshipRepublic of Turkey Ministry of Development Research Infrastructure Support Program
dc.description.sponsorshipThe authors gratefully acknowledge the use of the services and facil ities of the Koc University Research Center for Translational Medicine (KUTTAM), equally funded by the Republic of Turkey Ministry of Development Research Infrastructure Support Program. Findings, opin ions, or points of view expressed in this article do not necessarily represent the official position or policies of the Ministry of Development. Assistance in improving the English language and manuscript clarity was provided by ChatGPT (OpenAI, San Francisco, CA), a large language model. The authors take full responsibility for the integrity and content of the manuscript.
dc.identifier.doi10.1016/j.sna.2025.117391
dc.identifier.doi10.1016/j.sna.2025.117391
dc.identifier.issn0924-4247
dc.identifier.issn1873-3069
dc.identifier.scopus2-s2.0-105029851057
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.sna.2025.117391
dc.identifier.urihttps://hdl.handle.net/11411/10478
dc.identifier.volume399
dc.identifier.wosWOS:001654554800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofSensors and Actuators A-Physical
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260402
dc.snmzKA_Scopus_20260402
dc.subjectBiomechanical Measurements
dc.subjectCapsule Endoscopy
dc.subjectTactile Sensing
dc.subjectEarly Cancer Diagnosis
dc.titleA tactile sensing capsule endoscope employing force sensing cantilevers for tumor diagnosis in the GI tract
dc.typeArticle

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