Scalable psychological interventions for Syrian refugees in Europe and the Middle East: STRENGTHS study protocol for a prospective individual participant data meta-analysis
| dc.contributor.author | Uygun, Ersin | |
| dc.date.accessioned | 2022-10-25T09:08:06Z | |
| dc.date.available | 2022-10-25T09:08:06Z | |
| dc.date.issued | 2022-04-20 | |
| dc.description.abstract | Abstract: Introduction The World Health Organization's (WHO) scalable psychological interventions, such as Problem Management Plus (PM+) and Step-by-Step (SbS) are designed to be cost-effective non-specialist delivered interventions to reduce symptoms of common mental disorders, such as anxiety, depression and post-traumatic stress disorder (PTSD). The STRENGTHS consortium aims to evaluate the effectiveness, cost-effectiveness and implementation of the individual format of PM+ and its group version (gPM+), as well as of the digital SbS intervention among Syrian refugees in seven countries in Europe and the Middle East. This is a study protocol for a prospective individual participant data (IPD) meta-analysis to evaluate (1) overall effectiveness and cost-effectiveness and (2) treatment moderators of PM+, gPM+ and SbS with Syrian refugees. Methods and analysis Five pilot randomised controlled trials (RCTs) and seven fully powered RCTs conducted within STRENGTHS will be combined into one IPD meta-analytic dataset. The RCTs include Syrian refugees of 18 years and above with elevated psychological distress (Kessler Psychological Distress Scale (K10>15)) and impaired daily functioning (WHO Disability Assessment Schedule 2.0 (WHODAS 2.0>16)). Participants are randomised into the intervention or care as usual control group, and complete follow-up assessments at 1-week, 3-month and 12-month follow-up. Primary outcomes are symptoms of depression and anxiety (25-item Hopkins Symptom Checklist). Secondary outcomes include daily functioning (WHODAS 2.0), PTSD symptoms (PTSD Checklist for DSM-5) and self-identified problems (PSYCHLOPS). We will conduct a one-stage IPD meta-analysis using linear mixed models. Quality of evidence will be assessed using the GRADE approach, and the economic evaluation approach will be assessed using the CHEC-list. Ethics and dissemination Local ethical approval has been obtained for each RCT. This IPD meta-analysis does not require ethical approval. The results of this study will be published in international peer-reviewed journals. © Author(s) (or their employer(s)) 2022. | en_US |
| dc.fullTextLevel | Full Text | en_US |
| dc.identifier.doi | 10.1136/bmjopen-2021-058101 | en_US |
| dc.identifier.issn | 2044-6055 | |
| dc.identifier.pmid | 35443961 | en_US |
| dc.identifier.scopus | 2-s2.0-85128794094 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11411/4608 | |
| dc.identifier.uri | https://doi.org/10.1136/bmjopen-2021-058101 | |
| dc.identifier.wos | WOS:000784798300002 | en_US |
| dc.identifier.wosquality | Q1 | en_US |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.issue | 4 | en_US |
| dc.language.iso | en | en_US |
| dc.national | International | en_US |
| dc.numberofauthors | 10+ | en_US |
| dc.publisher | BMJ Publishing Group | en_US |
| dc.relation.ispartof | BMJ Open | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Anxiety disorders | en_US |
| dc.subject | Depression & mood disorders | en_US |
| dc.subject | MENTAL HEALTH | en_US |
| dc.title | Scalable psychological interventions for Syrian refugees in Europe and the Middle East: STRENGTHS study protocol for a prospective individual participant data meta-analysis | en_US |
| dc.type | Article | en_US |
| dc.volume | 12 | en_US |
