Evaluation of Atherosclerotic Risk by Oxidative Contributors in Alcohol Use Disorder

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dc.WoS.categoriesNeurosciencesPharmacology & Pharmacyen_US
dc.authorid0000-0003-0917-2098en_US
dc.contributor.authorSenat, Almila
dc.contributor.authorŞahin Kabadayı, Esra
dc.contributor.authorSöğüt, İbrahim
dc.contributor.authorDuymaz, Tomris
dc.contributor.authorÖzcan, Erel
dc.date.accessioned2023-09-21T08:32:24Z
dc.date.available2023-09-21T08:32:24Z
dc.date.issued2023-08
dc.description.abstractObjective: Alcohol Use Disorder (AUD) is a condition described as the inability to control or stop alcohol consumption. The patients with AUD have an increased risk of developing atherosclerosis-related diseases. The present study aimed to evaluate oxidative contributors of atherosclerotic risk factors in patients with AUD.Methods: The male subjects diagnosed with AUD (n = 45) and the male subjects as control (n = 35) were enrolled in this study. All participants were undergone psychiatric evaluation and sociodemographic tests. Also, serum oxidative contributors of atherosclerosis including myeloperoxidase (MPO), ferroxidase, catalase (CAT), and lipid hydroperoxides (LOOH) were measured. Additionally, serum lipid profile tests and atherogenic indicators including atherogenic index of plasma (AIP) and non-high-density lipoprotein (HDL) cholesterol were also analyzed.Results: The AUD subject had significantly elevated MPO activity and LOOH levels with decreased antioxidant capacity. AIP and non-HDL cholesterol levels, the atherogenic indicators, were also higher in AUD group compared to the control group. We found the MPO activity and LOOH levels were positively correlated with AIP, non-HDL cholesterol levels, and amount of alcohol consumption. Additionally, CAT activity was negatively correlated with duration of alcohol consumption. Conclusion: Our results revealed that MPO and LOOH levels were elevated by severe alcohol intake and the athero-genic indicators, AIP and non-HDL cholesterol, were significantly correlated alcohol induced elevated oxidative risk factors. Therefore, it can be suggested that MPO activity and LOOH levels may be useful to determine jeopardy of atherosclerotic and the therapeutic interventions that reduce oxidative load could be taken into account to prevent atherosclerotic diseases before clinical manifestation.en_US
dc.fullTextLevelFull Texten_US
dc.identifier.doi10.9758/cpn.22.1010
dc.identifier.issn2093-4327
dc.identifier.issn1738-1088
dc.identifier.pmid37424420en_US
dc.identifier.scopus2-s2.0-85168740758en_US
dc.identifier.urihttps://hdl.handle.net/11411/5201
dc.identifier.urihttps://doi.org/10.9758/cpn.22.1010
dc.identifier.wosWOS:001030118500011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.issue3en_US
dc.language.isoenen_US
dc.nationalInternationalen_US
dc.numberofauthors5en_US
dc.pages526-533en_US
dc.publisherKOREAN COLL NEUROPSYCHOPHARMACOLOGYen_US
dc.relation.ispartofCLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcohol use disorderen_US
dc.subjectAtherosclerosisen_US
dc.subjectLipid hydroperoxideen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectOxidative stressen_US
dc.titleEvaluation of Atherosclerotic Risk by Oxidative Contributors in Alcohol Use Disorder
dc.typeArticle
dc.volume21en_US

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