Cutaneous Leishmaniasis due to ThreeLeishmaniaSpecies Among Syrian Refugees in Sanliurfa, Southeastern Turkey

Basit Öğe Kaydı
dc.authoridGürses, Gülcan/0000-0002-8569-9863|Doni, Nebiye Yentur/0000-0002-0383-4970;
dc.authorwosidAksoy, Mustafa/AAA-2747-2021
dc.authorwosidGürses, Gülcan/GLT-6111-2022
dc.authorwosidDoni, Nebiye Yentur/AAD-5668-2019
dc.authorwosidYeşilova, Abdullah/AAX-2682-2020
dc.authorwosidZEYREK, FADİLE YILDIZ/AAA-5368-2021
dc.contributor.authorDoni, Nebiye Yentur
dc.contributor.authorGurses, Gulcan
dc.contributor.authorDikme, Resat
dc.contributor.authorAksoy, Mustafa
dc.contributor.authorZeyrek, Fadile Yildiz
dc.contributor.authorSimsek, Zeynep
dc.contributor.authorSatoskar, Abhay R.
dc.date.accessioned2024-07-18T20:49:16Z
dc.date.available2024-07-18T20:49:16Z
dc.date.issued2020
dc.departmentİstanbul Bilgi Üniversitesien_US
dc.description.abstractSanliurfa, a city in southeastern Turkey, is host to 477,166 Syrian refugees. The incidence of cutaneous leishmaniasis (CL) may be on the rise in areas affected by a refugee crisis, like Sanliurfa; thus, consequently, local uncommon species ofLeishmaniamay be encountered in these regions. This might potentially make diagnosis and treatment more challenging over time. In this study, it was aimed to identify the causative agents of CL in clinical samples. A total of 154 patients (60 Syrian and 94 Turkish) who were diagnosed with CL via microscopical examination and PCR were enrolled this study. All of the samples were analyzed using internal transcribed spacer 1 genes, restriction fragment length polymorphism, DNA-sequencing, and phylogenetic analyses. In this study,Leishmania tropicawas determined to be the predominant species in 140 of the patients (90.9%), followed byLeishmania majorin 12 patients (7.8%), andLeishmania infantumin 2 patients (1.3%). Of the 94 Turkish patients, 94.7% were infected withL. tropicaand 5.3% were infected withL. major, while none were infected withL. infantum.However, of the 60 Syrian patients, 85% were infected withL. tropica, 11.7% were infected withL. major, and 3.3% were infected withL. infantum. There was a significant association between theLeishmaniaspecies and the nations (Turkish-Syrian) (P < 0.001). The sequences were numbered from MH347941 to MH347953 and submitted to GenBank. This study confirmed thatL. tropica,L. major, andL. infantumcoexisted in Sanliurfa. This was the first time that the speciesL. infantumwas reported among recent immigrants from Syria in Sanliurfa. Therefore, it is necessary to discriminate theLeishmaniaspecies for diagnosis, treatment, and controlled studies in hyper-endemic regions.en_US
dc.description.sponsorshipHarran University Scientific Council [15132]en_US
dc.description.sponsorshipFunding was provided by the Harran University Scientific Council [Project No. 15132].en_US
dc.identifier.doi10.2478/s11686-020-00227-w
dc.identifier.endpage948en_US
dc.identifier.issn1230-2821
dc.identifier.issn1896-1851
dc.identifier.issue4en_US
dc.identifier.pmid32557082en_US
dc.identifier.scopus2-s2.0-85086704390en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage936en_US
dc.identifier.urihttps://doi.org/10.2478/s11686-020-00227-w
dc.identifier.urihttps://hdl.handle.net/11411/8134
dc.identifier.volume65en_US
dc.identifier.wosWOS:000544202800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofActa Parasitologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCutaneous Leishmaniasisen_US
dc.subjectGenotypingen_US
dc.subjectSequencingen_US
dc.subjectPhylogenetic Analysisen_US
dc.subjectSyrian Refugeesen_US
dc.subjectTurkeyen_US
dc.subjectIsoenzyme Characterizationen_US
dc.subjectMolecular-Identificationen_US
dc.subjectPhlebotomus-Sergentien_US
dc.subjectClinical-Featuresen_US
dc.subjectL-Majoren_US
dc.subjectDiagnosisen_US
dc.subjectInfantumen_US
dc.subjectDonovanien_US
dc.subjectPcren_US
dc.subjectInfectionen_US
dc.titleCutaneous Leishmaniasis due to ThreeLeishmaniaSpecies Among Syrian Refugees in Sanliurfa, Southeastern Turkey
dc.typeArticle

Dosyalar

Koleksiyon

Web of Science Indexed Publications
PubMed Indexed Publications
Scopus Indexed Publications